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Answered: Prokaryotic DNA is normally slightly negatively supercoiled, which can lead to "DNA breathing". How or why does supercoiling lead to DNA "breathing"? | bartleby
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Researchers have utilised atomic force microscopy and atomistic molecular dynamics simulations to resolve structures of negatively-supercoiled DNA minicircles at base-pair resolution. Read the paper, published in Nature Communications, here: https://go.nature.com/3qbcsgt | Nature Portfolio
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