Nuclear receptors bind directly to DNA regulating the expression of adjacent genes; hence these receptors are classified as transcription factors. [2][3] The regulation of gene expression by nuclear …

Jul 28, 2025 · This review summarizes the current understanding of nuclear receptors in both physiological and pathological contexts, providing insights into the signaling pathways they regulate.

The nuclear receptors (NRs) are an evolutionarily related family of transcription factors, which share certain common structural characteristics and regulate the expressions of various genes by …

Nuclear receptors are proteins found within cells, acting as sensors for various molecules such as steroid hormones, thyroid hormones, and vitamins. These receptors are located either in the …

Explore the structure, classification, and essential roles of nuclear receptors in gene regulation, metabolism, and hormone signaling across animals.

Nuclear receptors [NR] are a superfamily of transcription factors. They are modulated by and bind small lipophilic molecules (partial or mixed agonists) with low affinity.

Receptors for thyroid hormone (TRs), 1,25-dihydroxyvitamin D (VDRs), and retinoic acid (RARs) are called nuclear receptors because they are located in the nucleus already bound to DNA (nuclear …

Nuclear receptors are different from other receptors in that they are intracellular proteins (and not integrated into the cellular membrane). They are also known as transcription factors, because they …

Dec 17, 2021 · Nuclear receptors are classically defined as ligand-activated transcription factors that regulate key functions in reproduction, development, and physiology. Humans have 48 nuclear …

Jun 9, 2025 · Explore the crucial role of nuclear receptors in molecular and cellular biology, including their structure, function, and impact on various biological processes