How opioid use disorder occurs - Mayo Clinic
Jul 20, 2024 · Opioids act on the brain in powerful and potentially dangerous ways. Find out why no one is safe from opioid use disorder and learn what raises the risk.
Methadone (oral route) - Side effects & dosage - Mayo Clinic
Dec 1, 2025 · Methadone can cause serious unwanted effects if taken by adults who are not used to strong opioid pain medicines, children, or pets. Make sure you store the medicine in a safe and …
Tianeptine: Is safe use possible? - Mayo Clinic
Mar 29, 2024 · Taking high doses of tianeptine can be fatal. Some people take tianeptine with opioids, alcohol or other drugs to heighten the effects. Mixing these substances may lead to increased heart …
What are opioids and why are they dangerous? - Mayo Clinic
Aug 26, 2023 · Opioid medicines travel through the blood and attach to opioid receptors in brain cells. This blocks pain messages and can boost feelings of pleasure. When opioid medicines are …
Kratom: Unsafe and ineffective - Mayo Clinic
Jun 18, 2024 · Kratom starts to work in minutes. The effects last a few hours. The more kratom you take, the stronger the effects are. Depending on the amount of active ingredient in the product and the …
Xylazine - Mayo Clinic
Feb 14, 2024 · Xylazine is often mixed with heroin, fentanyl and other opioids that are taken illegally. Mixing these drugs with xylazine can increase the effects some people feel when taking them. …
Poppy seed tea: Beneficial or dangerous? - Mayo Clinic
Jul 4, 2024 · The effects of the tea can begin within 15 minutes and last up to 24 hours. Knowing the symptoms of poppy seed tea overdose is necessary for those drinking it. Poppy seed tea overdose …
Drug addiction (substance use disorder) - Symptoms and causes
Jun 20, 2025 · Overview Drug addiction, also called substance use disorder, is a disease that affects a person's brain and behavior and leads to an inability to control the use of a legal or illegal drug or …
Fentanyl (nasal route) - Side effects & dosage
Dec 1, 2025 · However, elderly patients may be more sensitive to the effects of opioid analgesics than younger adults and are more likely to have age-related kidney disease, which may require caution …
Kratom for opioid withdrawal: Does it work? - Mayo Clinic
Dec 30, 2023 · Kratom is promoted as an aid in overcoming withdrawal from opioid medications, but research suggests that it leads to more health problems than it solves.