The raw material for de novo fatty acid synthesis is acetyl-CoA, which can be obtained via the citrate shuttle pathway or from acetic acid. ACC and FASN catalyze the conversion of acetyl-CoA into ...
GRAND RAPIDS, Mich. (Aug. 22, 2024) — Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel ...
Researchers have discovered the reason why immune cells lose energy when they enter the solid tumor microenvironment -- and how to restore their energy levels. A metabolic enzyme, called Acetyl-CoA ...
"Like any good system, immune cells have a plan A and a plan B," said Russell Jones, Ph.D., the study's corresponding author and chair of VAI's Department of Metabolism and Nutritional Programming.
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