Identifying the mechanisms of action driving a drug’s anti-cancer efficacy is critical for identifying optimal biomarkers, indications, and combinations for clinical success. Yet, systematically ...

Biomarkers are key to the development of biological drugs, offering vital insights into drug mechanisms of action (MOA), informing clinical study design, and optimizing treatment strategies.

Ten structures of URAT1 obtained by scientists provide a deep understanding of the mechanism of urate transport to guide gout therapeutic design. Scientists at St. Jude Children's Research Hospital ...

Although drug eruptions are often linked to the human leukocyte antigen (HLA), the mechanism of its involvement in presenting symptoms of the skin remains unclear. In a recent study, researchers used ...

HONOLULU — Glovadalen (UCB), an investigational brain-penetrant D1 receptor positive allosteric modulator (D1 PAM), is both safe and effective for patients with advanced Parkinson’s disease (PD), new ...

The obesity drug liraglutide cut migraine days in half in a small trial, though more research is needed to exclude the placebo effect, researchers said. When you purchase through links on our site, we ...