Nature

Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα

Phosphatidylinositol 4-kinase IIα (PI4KIIα), a membrane-associated PI kinase, plays a central role in cell signalling and trafficking. Its kinase activity ...

A short-lived kinase state that's essential for normal cell migration and T-cell function

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src ...
Nature

Targeting Bruton's tyrosine kinase in B cell malignancies

Bruton's tyrosine kinase (BTK) was originally identified as a non-receptor protein tyrosine kinase that is defective in the inherited immunodeficiency disease X-linked agammaglobulinaemia (XLA). BTK ...
News-Medical.Net on MSN

Hidden kinase state enables rapid and repeated protein phosphorylation

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...