The viral protein, called AcrVA2, is the only known anti-CRISPR that sabotages CRISPR this way. "When we first put AcrVA2 into bacterial cells with Cas12, we saw Cas12 disappear," said Joseph ...

The CRISPR-Cas gene scissors offer a wide range of potential applications, from the treatment of genetic diseases to antiviral therapies and diagnostics. However, to safely harness their powers, ...

In a new study publishing November 19 in the Cell Press journal Trends in Biotechnology, researchers used a gene-editing technology called CRISPR to increase a fungus's production efficiency and cut ...

A handful of start-up firms are testing therapies that target specific epigenetic markers to treat everything from high ...

A team of researchers led by Alan Davidson at the University of Toronto have discovered a small protein that can disassemble a stable bacterial CRISPR-Cas7 complex without using adenosine ...

(a) CRISPR/Cas9-based gene editing mechanism in PD; (b) Regulation of transcription using CRISPR and Cas9. AC, activating Cas; dCas9, dead Cas9; Me, methylation; PAM, protospacer adjacent motif; PD, ...

An international multidisciplinary team has demonstrated for the first time that CRISPR-based gene activation (CRISPRa) can be used to treat genetic heart disease in vivo. The study, published in the ...

Researchers from Skoltech—a VEB.RF group institution—and their colleagues from the U.S. and China have explained how the ...

Across all domains of life, immune defenses foil invading viruses by making it impossible for the viruses to replicate. Most known CRISPR systems target invading pathogens' DNA and chop it up to ...

Bacteria fend off invading viruses with molecular scissors that slice up viral DNA — a system called CRISPR that’s become indispensable to gene editing. But viruses can fight back with a molecular ...